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DiscoverX PI3-Kinase (p110alpha(E542K) p85alpha) murine 14-791-K
品牌：Eurofins DiscoverX
貨號(hào)：14-791-K
規(guī)格：14-791-K
貨期：DiscoverX
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品牌：DiscoverX 品名：PI3-Kinase (p110α(E542K)/p85α) murine 貨號(hào)：14-791-K 規(guī)格：Bulk

商品詳情 參考文獻(xiàn) 相關(guān)資料

品牌：DiscoverX
品名：PI3-Kinase (p110α(E542K)/p85α) murine
貨號(hào)：14-791-K    
規(guī)格：Bulk  


簡(jiǎn)要說(shuō)明：

PI3-Kinase (p110α(E542K)/p85α) murine

Complex of N-terminal 6His-tagged recombinant, murine p110α full length, containing the mutation E542K, and untagged, recombinant, murine p85α full length. The E542K substitution is a somatic mutation in p110α that has been associated with tumours of the colon and brain. Combined in vitro and in vitro studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. (Kang S. et al., PNAS, (2005);102: 802-807 and Zhao J.J. et al., PNAS, (2005);102:18443-18448).


產(chǎn)品介紹：

Target
PI3Kα/p85α
Expression System
Expressed by baculovirus in Sf21 insect cells
Application
Kinase Assay
Molecular Weight
129 kDa (p110α E542K), 84 kDa (p85α)
Accession Number
BC089038
Species
Mouse
Tag
6His
Purification Method
Ni2+/NTA-agarose
Content
Protein in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 0.2mM PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
Storage
6 months at -70°C
Bulk Sizes
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