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Anti-MMP9 (W680) Antibody

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規(guī)格：50μl

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Anti-MMP9 (W680) Antibody

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Overview

Name:	Anti-MMP9 (W680) Antibody See all MMP9 primary antibodies
Description:	Rabbit polyclonal antibody to MMP9 (W680)
Specificity:	MMP9 (W680) pAb detects endogenous levels of MMP9 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 650-700 of Human MMP9.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 92 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-\|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
Tissue Specificity:	Produced by normal alveolar macrophages and granulocytes.
Involvement in Disease:	Intervertebral disc disease: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. Metaphyseal anadysplasia 2: A bone development disorder characterized by skeletal anomalies that resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia.
Sequence Similarities:	Belongs to the peptidase M10A family.
Post-Translational Modification:	Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
Cellular Location:	Secreted > Extracellular space > Extracellular matrix.
Database Links:	Entrez Gene: 4318?Human Entrez Gene: 17395?Mouse Entrez Gene: 81687?Rat Omim: 120361?Human SwissProt: P14780?Human SwissProt: P41245?Mouse SwissProt: P50282?Rat Unigene: 297413?Human Unigene: 4406?Mouse Unigene: 10209?Rat
Synonyms:	82 kDa matrix metalloproteinase-9 Antibody 92 kDa gelatinase Antibody 92 kDa type IV collagenase Antibody CLG 4B Antibody CLG4B Antibody Collagenase Type 4 beta Antibody Collagenase type IV 92 KD Antibody EC 3.4.24.35 Antibody Gelatinase 92 KD Antibody Gelatinase B Antibody Gelatinase beta Antibody GelatinaseB Antibody GELB Antibody Macrophage gelatinase Antibody MANDP2 Antibody Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) Antibody Matrix Metalloproteinase 9 Antibody MMP 9 Antibody MMP-9 Antibody MMP9 Antibody MMP9_HUMAN Antibody Type V collagenase Antibody
Information:	Target information shown above is from the UniProt Consortium.